Postoperative nausea and vomiting: what about substance P antagonism? (or is it just another empty promise?)

Eddie Oosthuizen

Abstract


Nausea and vomiting are now considered to be ultimately mediated by a central common pathway. Neurokinin 1 (substance P) is the synaptic mediator at this level. Aprepitant is a substance P antagonist at neurokinin 1 receptors and is now available in North America for the prevention of postoperative nausea and vomiting. A basic summary is provided on the physiological and pharmacological basis of this agent.


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