pKa and Ka (Acid dissociation constant)

G Manjooran

pKa and Ka (Acid dissociation constant)

Authors

G Manjooran University of the Witwatersrand https://orcid.org/0000-0002-9838-4676

Keywords:

pKa, Ka, acid dissociation constant

Abstract

pK_a of a drug is the pH at which 50% of the drug is ionised and 50% is not ionised/unionised.^1,2

The pK_a is specific for each drug and these properties determine how a drug can be administered, the speed of absorption as well as speed of excretion by the kidneys.²

Author Biography

G Manjooran, University of the Witwatersrand

Department of Anaesthesia, University of the Witwatersrand, South Africa

Downloads

Published

2020-11-13

Issue

Vol. 26 No. 6 (2020)

Section

FCA 1 Anaesthetic Refresher Course 2020

License

By submitting manuscripts to SAJAA, authors of original articles are assigning copyright to the SA Society of Anaesthesiologists. Authors may use their own work after publication without written permission, provided they acknowledge the original source. Individuals and academic institutions may freely copy and distribute articles published in SAJAA for educational and research purposes without obtaining permission.

The work is licensed under a Creative Commons Attribution-Non-Commercial Works 4.0 South Africa License. The SAJAA does not hold itself responsible for statements made by the authors.