Effect of hydroxyethyl starch (Voluven® 6% 130/0.4) on blood glucose levels during orthopaedic lower limb surgery under spinal anaesthesia – a prospective, randomised controlled trial

KN van Rensburg

Effect of hydroxyethyl starch (Voluven® 6% 130/0.4) on blood glucose levels during orthopaedic lower limb surgery under spinal anaesthesia – a prospective, randomised controlled trial

Authors

KN van Rensburg Walter Sisulu University https://orcid.org/0009-0006-0546-9993

Abstract

Hydroxyethyl starch (HES) is similar to glycogen as it is derived from amylopectin. It consists of ethylated polysaccharides and glucose polymers that are metabolised into smaller residues, including glucose, resulting in the potential to induce or potentiate hyperglycaemia. It was hypothesised that Voluven^® 6% (130/0.4) – a third generation saline-based product with a lower molecular weight, molar substitution, and a C₂/C₆ ratio greater than eight compared to previous first and second generation HES – could be more easily hydrolysed by α-amylase and release glucose residues at a more rapid rate.

Author Biography

KN van Rensburg, Walter Sisulu University

Walter Sisulu University, South Africa

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Published

2024-09-06

Issue

Vol. 30 No. 4 (2024)

Section

Letters to the Editor

License

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